Photodynamic therapy triggered by spectral scanner CT: an efficient tool for cancer treatment




The Institut National de la Santé et de la Recherche Médicale (INSERM) is the only public research organization in France entirely dedicated to human health. Its objective is to promote the health of all by advancing knowledge about life and disease, treatment innovation, and public health research. Inserm brings together 15,000 researchers, engineers, technicians, and administrative staff around one common goal: to improve the health of all by advancing knowledge of life and disease, innovation in treatment, and public health research through about 200 Research Units.
Among them, two Units (UA7 and UA8) will participate to this project.

Inserm UA7 unit Synchrotron Radiation for Biomedicine (STROBE) is a collaborative research unit supported by the University of Grenoble, at the European Synchrotron Radiation Facility. It is directed by Prof. Sam Bayat. The goal of the unit is to foster the advancement of basic, translational and clinical scientific research, taking full advantage of the unique possibilities offered by high energy synchrotron radiation sources. Specifically, the scientific goals of the unit include synchrotron x-ray imaging, including the exploration of subcellular structures and their chemical composition at the nanoscale, as well as applications of synchrotron radiation to radiotherapy and radiosurgery. The unit has a long-standing track record in the field. It has organized the international congress on Medical Application of Synchrotron Radiation (MASR) in 2001 and 2015, that regularly occurs every 3-years. It has also federated a COST H2020 SYRA3 and is participating in COST RADIOMAG and EXTREMA.

Sylvain BOHIC is senior researcher at UA7-STROBE. He did some pioneer work on single-cell chemical imaging and metal ions in neurodegenerative disease particularly Parkinson’s disease (paper in Neurobiol. Aging cited 118 times since 2014). His research interests and recognized expertise are on cellular cryo-preparation and mesoscale metal imaging in biological tissues and in cells using synchrotron based methods and micro/nano-spectromicroscopy techniques for quantitative imaging and speciation. He is currently funded by the French National Research Agency, the National Institutes for Cancer (INCA) and some PhDs joinly funded by the UGA/ESRF.